The effects of the aqueous crude extract (5%) of Eugenia punicifolia on cholinergic nicotinic neurotransmission were investigated. Actions of. Eugenia punicifolia (Kunth) DC (Myrtaceae), popularly known as pedra-ume-caĆ”, pedra-ume, murta, or muta, is a shrub found mainly in the. Figure 16 Body weight evolution in rats with acetic acid-induced gastric ulcers treated with oral administration of vehicle, lansoprazole.

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Macroscopic analyses and weighing of the vital organs liver, kidneys, heart, spleen, and lungs were performed at the end of the treatment. Qin et al[ 58 ] shows that estrogen can induce apoptosis in gastric cancer cells, and that Bcl-2 might be involved in this effect. After electrophoresis, the gels were subjected to two 15 min washes in a solution of 2. To determine the protein expression profiles associated with HEEP-mediated healing of gastric ulcers, we examined the western blotting gels for several important contributors to cell growth and cell death.

Cellular and molecular mechanisms of gastric ulcer healing. Herbal combination preparations are popular among traditional herbal medicine practitioners. The in vivo experiments used male g and female g Wistar albino rats obtained from the breeding facility of the State University of Campinas Multidisciplinary Center for Biological Research.

Beach Cherry – Eugenia punicifolia

Quality of healing of gastric ulcers: We used a rat model of acetic acid-induced gastric ulcers to evaluate the healing effect of HEEP. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: The stomach was bathed with saline to avoid adherence to the external surface of the ulcerated region, and the abdomen was closed.


An overview of acetic acid ulcer models–the history and state of the art of peptic ulcer research. Extraction of total protein from the ulcer tissue. June 13, First decision: All treatments were delivered orally once daily beginning one day after surgery and continuing for 14 d. Number of Hits and Downloads for This Article. The animals eugsnia not anesthetized prior to decapitation, since anesthetics may interfere with the results of the biochemical parameters evaluated.

Fugenia rufum Purple Guava. The animal protocol was designed to minimize pain or discomfort to the animals. Growth factors such as EGF activate epithelial cell migration and proliferation, accelerating wound and ulcer healing in vivo and in vitro [ 5737 ].

The dried and crushed leaves 10 g of plant material were dissolved in mL of solvent consisting of a Organ weights following the d treatment of ovariectomized rats with acetic acid-induced gastric ulcers with lansoprazole and hydroalcoholic extract from the leaves of Eugenia punicifolia.

Gastric ulcers, which result from an imbalance between the protective and aggressive agents at the surface of the gastric mucosa, is a chronic disease that affects millions around the world and has high relapse rates[ 12 ]. June 13, First decision: While such treatments are effective, prolonged use of anti-secretory drugs, especially ranitidine and proton pump inhibitors, is associated with several side effects[ 4 eugeina and poor healing of the gastric mucosa[ 5 ].

Berg Eugenia pungens var. Please review our privacy policy. They can be grown in full sun from sea level to altitudes of m. Eugeni Eugenia arctostaphyloides var. A critical role of serum response factor in eugejia differentiation during experimental oesophageal ulcer healing in rats. For this purpose, we employed a rat model of acetic acid-induced gastric ulcers and analyzed the curative action of HEEP in males, intact females, and punicifoloa females.


July 4, Article in press: The acetic acid-induced gastrointestinal ulcer model is a classical model that has proven suitable for investigating the effect of treatment on the healing process of chronic gastrointestinal ulcers[ 28 ], provided that the wounds resemble human ulcers that do not heal naturally[ 293031 ].

D Grade E Poor: Syzygium cuminii Java Plum. The conventional treatment for gastric ulcers is associated with several side effects pknicifolia poor healing of the gastric mucosa.

Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.

Eugenia punicifolia (Kunth) DC.

Finally, the protein content was quantified using the biuret method[ 2526 ]. Can be planted in full sun in space at a distance of 3 x 3 metersthe hole should measure the depthwidth and length of 50 cm eachshould be filled 30 cm of well- mixed, fertile soil in 18 liter gritty sand4 kg of well mixed manureg of lime and 1 kg of wood ash.

We measured prostaglandin levels, analyzed the extracellular matrix by zymography, evaluated the quality of ulcer healing by western blot, and assessed the healing activity by scratch assay. The following chemicals and reagents were used: However, this therapy is associated with several side effects and poor quality of ulcer healing. A method for experimental, penetrating gastric and duodenal ulcers in rats.