DISGENESIA GONADAL XY PDF

Disease definition. 46,XY partial gonadal dysgenesis (46,XY PGD) is a disorder of sex development (DSD) associated with anomalies in gonadal development. 46,XY complete gonadal dysgenesis (46,XY CGD) is a disorder of sex development (DSD) associated with anomalies in gonadal development that result in the. Statistics. Original breve. Pubertad precoz periférica: disgenesia gonadal completa 46 XY. Peripheral precocious puberty: 46, XY complete gonadal dysgenesis.

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Diagnostic methods Diagnosis is made by cytogenetic analysis of chromosome status. Etiology Although the etiology is not completely understood, 46,XY CGD results from failure of testicular development due to disruption of the underlying genetic pathways and several genes have been implicated: Swyer syndrome represents one phenotypic result of a failure of the gonads to develop properly, and hence is part of a class of conditions termed gonadal dysgenesis.

Fraiser syndrome, part of the Denys-Drash continuum or simply a WT1 gene associated disorder of intersex and nephropaty? Are you a health professional able to prescribe or dispense drugs?

Disgenesia gonadal XY

Development ; suppl: HR Atrichia with papular lesions. Clinical reevaluation in search for dysmorphic signs did not reveal significant abnormalities. Birth weight was 1, g, length 39 cm and head circumference 29 cm all below the 3 rd centile. From Wikipedia, the free encyclopedia.

Am Disgenesiw Med Genet ; Without testosteronethe wolffian ducts fail to develop, so no internal male organs are formed. As they are not metastatic tumors and may be eradicated by selective excisions, the importance of detecting Y-sequences by molecular sensitized techniques is stressed in order to indicate prophylactic gonadectomy.

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Depending on further evaluations, particularly hormone measurements, surgical exploration and gonadal biopsy may be necessary to reach a specific diagnosis 1,2. They appear to be normal girls and are generally considered so.

Clitoromegaly Progestin-induced virilization Pseudohermaphroditism True hermaphroditism. Clinical description Patients present during adolescence or early adulthood with normal female external genitalia but lack pubertal development although adrenarche is normal. This finding changed the diagnosis from 46,XY DSD, partial gonadal dysgenesis, to sex glnadal DSD, mixed gonadal dysgenesisthe prognosis short stature, risk of cardiovascular, renal and urinary anomalies, autoimmune thyroid disease, among others and the follow-up of the child which must be similar to those of Turner syndrome patients 8and also brought the possibility of hGH treatment to improve final height 9.

Summary Epidemiology The prevalence is unknown. How to cite this article. Hum Genet ; Summary and related texts. The histological picture of a dysgenetic testis ranges from a gonad with predominance of fibrous tissue and a few tubular structures to only a reduction in tubular size and reduced number of germ cells. CiteScore measures average citations received per document published. J Pediatr Rio ; Consensus statement on management of inter-sex disorders.

Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Although an XY karyotype can also indicate a person with complete androgen insensitivity syndromethe absence of breasts, and the presence of a uterus and eisgenesia hair exclude the possibility.

A forma com surdez foi descrita por Perrault e col. There are several forms of gonadal dysgenesis. Detailed information Professionals Summary information Greekpdf Polskipdf.

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Orphanet: Disgenesia gonadal parcial 46 XY

Disease definition 46,XY complete gonadal dysgenesis 46,XY CGD is a disorder of sex development DSD associated with anomalies in gonadal development that result in the presence of female external and internal genitalia despite the 46,XY karyotype.

The number of cells analyzed in karyotyping is critical. Heredity and cancer in man. The karyotype reveals XY chromosomes and the imaging demonstrates the presence of a uterus but no ovaries the streak gonads are not usually seen gonaadl most imaging.

XY gonadal dysgenesis

Neoplasia associated with anomalous sexual development and abnormal sex chromosomes. Diagnostic methods Diagnosis is made on the basis of clinical findings with gonaval analysis, endocrine investigations, molecular genetic studies, and sometimes surgical exploration with biopsy.

In this case, as the child had normal LH, FSH and testosterone levels, a testis in the scrotal fold and good response to testosterone injections, he had a male sex assignment. How to cite this article.

Other examples include complete androgen insensitivity syndromepartial X chromosome deletions, lipoid congenital adrenal hyperplasiaand Turner syndrome. Although Y-specific sequences are seldom cytogenetically evident, dysgenetic gonads are potentially prone to developing tumors. Arch Fr Pediatr ; EmTsuchiya e cols. With early diagnosis, surgery and hormone treatment can result in good outcome, both cosmetically and functionally. The uterus gonadla of variable xisgenesia and the degree of differentiation of the internal genitalia varies.